Laboratory of Molecular Endocrinology

Axis Hypothalamus-Pituitary-Thyroid and Thyroid Hormone

    The Laboratory of Molecular Endocrinology was created in 2000 from the consolidation of a group originated in the early 90's in UERJ and in 1993 moved to the Laboratory of Endocrine Physiology IBCCF, where he had the opportunity to develop.

    Our studies seek to understand the operation in physiological and pathophysiological situations, the hypothalamic-pituitary-thyroid hormone action and tireiodeanos. To do so, we combine techniques in vivo and in vitro, with molecular approaches. A major focus of our research has been to control the secretion of thyrotropin or TSH, the main stimulator of thyroid function. We studied the role of regulators hormonal and neurohormonal as sex steroids and somatostatin, respectively, over the control adeno-secreting pituitary TSH.

    Furthermore, we have devoted ourselves to the characterization of new local factors in the adenohypophysis, such as the peptides of the bombesin family, particularly Neuromedin B Recently, we confirmed the physiological role of this peptide inhibitor of TSH secretion.

Currently, we use as a study model knockout animals for the neuromedin B receptor that has allowed us to evaluate the functional consequences for the hypothalamic-pituitary-thyroid absence of this receptor. This study is being conducted in collaboration with Dr. Etsudo Wada, Department of Neurological Degenerative Diseases, National Institute of Neuroscience, University of Tokyo, Japan

    Another line developed currently aims to understand the interaction of leptin with hypothalamic-pituitary thyroid ¬. Already characterize the inhibitory effect of this hormone on the spot TSH secretion. Studies with leptin are particularly interesting due to their relationship with obesity. Right now, we are exploring the interaction between leptin and thyroid hormone action.

    We study also key determinants of colon tissue action of thyroid hormones: the enzymes 5 '¬ deiodinases, responsible for most of the formation of active thyroid hormone, T3, and thyroid hormone receptors. In this regard, we are interested in the identification of new target genes modulated by thyroid hormones, especially in heart tissue.

    Recently, we incorporate other models of genetically modified mice. This interest arose after working with Dr. Fredric Wondisford initially at Harvard Medical School (Harvard Medical School) and later at the University of Chicago, where he developed models of transgenic mice to study the syndrome of Human Resistance to Thyroid Hormone, wherein the presence of mutant receptors for these hormones leads to changes in gene expression and physiology of organs.

    These models have allowed us to better study the pathophysiology of the syndrome and mostly reveal new aspects of the action of thyroid hormones, via their nuclear receptors.

    Our group has contributed to the training of staff in both the undergraduate and graduate levels. Doctors graduates this group today are professors and researchers at the Institute, the State University of Rio de Janeiro, and the Universidade Federal Fluminense.

Staff

 Carmen Cabanelas Pazos de Moura - Head of the laboratory

Tânia Maria Ortiga Carvalho - Associate professor

Isis Hara Trevenzoli

Post-doctoral fellows

Enrrico Bloise

PhD students

Bruna Pereira Lopes

Camila Calvino Moraes

Larissa Costa Faustino

Marcio Dytz

Master students

Lorraine Soares de Oliveira

Aline Fonseca

Mila Reginatto

Roberto Azevedo Antunes

Undergraduate students

Adriana Cabanelas

Aline Cordeiro

Juliana Franco

Luana Lopes Souza

Ricardo Henrique Costa e Sousa

Bartira Pizarro

Camilla Pereira D.da Rocha

Eliete Cristina de Souza

Guilherme Faria

Henrique Nunes Almeida

Klaus Novaes

Natalia Liacone da Silva

Nina Bressan;

André Souza e Silva

Marianna Wilieman

Technicians

Juliana P.Gonçalves

Luela Luan P. Mouta

Programa: 
Physiology and Cellular Biophysics